Two totally different bikes.
I like the V-star but it certainly isn't a fast bike. If you are going to be doing any long distance highway riding, I'd probably lean toward to V-Strom.
For what it is worth, my dad has about 5 bikes; everything from an HD Ultra Classic to a Buell XB12S, a jap inline and a metric cruiser. His V-Star 650 is his favorite of the bunch.
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