i wouldnt plug, only patch. A few things that do come to mind about tires is that they do expand at speed and what holds them together are the belts and cords built into the tires. Sometimes punctures hit and cut cords or belts and cause a bulge in the sidewall where the rubber is no longer supported. If there are any bulges or deformities after ther repair i wouldnt trust it at all.
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If you cant eat it or hump it piss on it and walk away. 
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